Alpha‐globin gene mutation spectrum in patients with microcytic hypochromic anemia from Mazandaran Province, Iran
نویسندگان
چکیده
منابع مشابه
Microcytic hypochromic anemia patients with thalassemia: genotyping approach.
BACKGROUND Microcytic hypochromic anemia is a common condition in clinical practice, and alpha-thalassemia has to be considered as a differential diagnosis. AIMS This study was conducted to evaluate the frequency of alpha-gene, beta-gene and hemoglobin variant numbers in subjects with microcytic hypochromic anemia. SETTING AND DESIGNS Population-based case-control study in the Iranian popul...
متن کاملmolecular analysis of alpha globin gene deletions among patients with microcytic hypochromic anemia in kermanshah-iran
background: the majority of α-thalassemi mutations are deletions of one or both α-globin genes. since the iranian populaion is a mixture of different ethnic groups, frequency and distribution of globin mutations in various regions of the country need to be clarified. the aim of this study was to determine the common alpha globin gene deletions among individuals with hypochromic microcytic anemi...
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The group of 17 irradiated rats including the animal that produced anemic progeny (X2) belonged to a stock of rats randomly bred in our laboratory since 1930. The X2 female was one of five females in a litter, which were X-irradiated under conditions reported earlier (SLADICSIMIC et al. 1963). All irradiated females were mated with normal males from the stock and brother-sister matings for each...
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Idiopathic pulmonary hemosiderosis (IPH) is a rare, life-threatening disease of uncertain etiology, characterized by recurrent intra-alveolar hemorrhages and usually afflicting young adults or children(l). Symptoms of lung hemorrhage are often few and atypical(2). Consequently, the condition may go unrecognized for a few years or months, presenting as recurrent iron deficiency anemia with no ac...
متن کاملRED CELLS hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse
Mouse models have proven invaluable for understanding erythropoiesis. Here, we describe an autosomal recessive, inherited anemia in the mouse mutant hem6. Hematologic and transplantation analyses reveal a mild, congenital, hypochromic, microcytic anemia intrinsic to the hematopoietic system that is associated with a decreased red blood cell zinc protoporphyrin to heme ratio, indicative of porph...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2019
ISSN: 0887-8013,1098-2825
DOI: 10.1002/jcla.23018